分子量:12.5 kDa

纯度:>92% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human S100A14, His Tag by the LAL method.

Buffer:50 mM Tris,150 mM NaCl,pH8.0

生物活性:

产品特性:Human S100A14, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 12.5 kDa. The predicted N-terminus is Met 1. The reducing (R) protein migrates as 13 kDa in SDS-PAGE .

产品背景:Protein S100-A14 (S100A14) is also known as S100 calcium-binding protein A14 (S114),which belongs to the S-100 family, containing one EF-hand domain.S100A14 is a homodimer can interact with AGER. S100A14 can modulate P53/TP53 protein levels, and play a role in the regulation of cell survival and apoptosis at different concentrations via receptor for advanced glycation end products (RAGE).S100A14 also plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53.